The Science Behind Why The Skin Around the Eyes Ages Differently
2 min read
THE ONESKIN TEAM
February 28,2023
SKIN SCIENCE
The Science Behind Why The Skin Around the Eyes Ages Differently
2 min read
THE ONESKIN TEAM
February 28,2023
SKIN SCIENCE
For decades, the beauty industry has taught us that we need a special product for our under-eyes because the skin there is fundamentally different from the skin on our cheeks and our chins. But have you ever found yourself wondering if that’s actually true?It turns out, there’s some interesting science to back it up. Research suggests that the skin around our eyes actually ages differently than skin on the rest of the face–and shows visible signs of aging when we’re still very young. In fact, a recent study found that under-eye wrinkles are the most pronounced visible signs of aging in women ages 20-29. [1] Let’s take a closer look at what makes under-eye skin different from other areas of the face–and what you can do to keep it healthy.
For decades, the beauty industry has taught us that we need a special product for our under-eyes because the skin there is fundamentally different from the skin on our cheeks and our chins. But have you ever found yourself wondering if that’s actually true?It turns out, there’s some interesting science to back it up. Research suggests that the skin around our eyes actually ages differently than skin on the rest of the face–and shows visible signs of aging when we’re still very young. In fact, a recent study found that under-eye wrinkles are the most pronounced visible signs of aging in women ages 20-29. [1] Let’s take a closer look at what makes under-eye skin different from other areas of the face–and what you can do to keep it healthy.
01
Under-Eye Skin Is Thinner
The skin around the eyes is among the thinnest on the body, with the stratum corneum being on average about 3 layers thick compared to 15+ layers on other areas. [2] The skin is so thin that you can sometimes actually see through it. If you have light skin and struggle with dark circles, you likely have that very thin, transparent under-eye skin to thank. What you’re actually looking at when you see dark circles are subdermal features like hollowness and pooled blood that appear blue or purple beneath thin under-eye skin. [3]This incredible skin thinness means your under eyes experience more exaggerated signs of collagen and elastin loss–namely fine lines, sagging, and crepiness. [1,3] This may be partly due to a weaker skin barrier around the eyes. When the skin barrier is weaker, it experiences higher rates of transepidermal water loss, leaving the skin more vulnerable to environmental aggressors that degrade skin firmness and resilience. [1] So even though your under eyes and forehead are exposed to similar environmental conditions, your under eyes will be impacted more.
01
Under-Eye Skin Is Thinner
The skin around the eyes is among the thinnest on the body, with the stratum corneum being on average about 3 layers thick compared to 15+ layers on other areas. [2] The skin is so thin that you can sometimes actually see through it. If you have light skin and struggle with dark circles, you likely have that very thin, transparent under-eye skin to thank. What you’re actually looking at when you see dark circles are subdermal features like hollowness and pooled blood that appear blue or purple beneath thin under-eye skin. [3]This incredible skin thinness means your under eyes experience more exaggerated signs of collagen and elastin loss–namely fine lines, sagging, and crepiness. [1,3] This may be partly due to a weaker skin barrier around the eyes. When the skin barrier is weaker, it experiences higher rates of transepidermal water loss, leaving the skin more vulnerable to environmental aggressors that degrade skin firmness and resilience. [1] So even though your under eyes and forehead are exposed to similar environmental conditions, your under eyes will be impacted more.
02
Under-Eye Skin Ages Faster
Do you feel like your eyes are aging faster than the rest of your face? You might be right. Because it’s so thin and vulnerable, periocular skin actually does age faster than other areas of the face. In a study, scientists measured the biological age of eye skin and compared it to skin just inches away on the temple. What they found was that the skin under the eyes was biologically 22.25 years older. The difference was even more pronounced in skin from the upper eyelid, which was on average 28.75 years older than skin on the temples. [1]
02
Under-Eye Skin Ages Faster
Do you feel like your eyes are aging faster than the rest of your face? You might be right. Because it’s so thin and vulnerable, periocular skin actually does age faster than other areas of the face. In a study, scientists measured the biological age of eye skin and compared it to skin just inches away on the temple. What they found was that the skin under the eyes was biologically 22.25 years older. The difference was even more pronounced in skin from the upper eyelid, which was on average 28.75 years older than skin on the temples. [1]
03
Under-Eye Skin Experiences Higher Cellular Senescence
To fully understand why under-eye skin ages faster, it’s important to look at the cellular factors behind accelerated skin aging. Research points to cellular senescence, one of the primary factors behind most biological aging in the body. Seeing increased cellular senescence in skin cells is a telltale sign that the skin is aging more rapidly.In a study, scientists analyzed the expression of a key senescence marker, CDK2NA, in periocular skin. What they found was that periocular skin expressed significantly higher levels of cellular senescence than other areas of the face. This suggests that this delicate skin not only ages faster, but also loses its ability to efficiently repair and regenerate damage. In fact, in the same study, scientists found that DNA repair pathways were lower in periocular skin, suggesting that DNA repair insufficiency may be an underlying factor in rapid signs of visible aging. [1]
03
Under-Eye Skin Experiences Higher Cellular Senescence
To fully understand why under-eye skin ages faster, it’s important to look at the cellular factors behind accelerated skin aging. Research points to cellular senescence, one of the primary factors behind most biological aging in the body. Seeing increased cellular senescence in skin cells is a telltale sign that the skin is aging more rapidly.In a study, scientists analyzed the expression of a key senescence marker, CDK2NA, in periocular skin. What they found was that periocular skin expressed significantly higher levels of cellular senescence than other areas of the face. This suggests that this delicate skin not only ages faster, but also loses its ability to efficiently repair and regenerate damage. In fact, in the same study, scientists found that DNA repair pathways were lower in periocular skin, suggesting that DNA repair insufficiency may be an underlying factor in rapid signs of visible aging. [1]
04
Reverse Biological Aging with the OS-01 peptide
So what can you do to support the delicate skin around your eyes? The answer is OS-01, the first peptide proven to reverse skin’s biological age by reducing the accumulation of senescent cells. [4,5] Stay tuned this month as we reveal key data behind the OS-01 peptide and our latest innovation: OS-01 EYE, a targeted treatment formulated with our highest concentration of the OS-01 peptide to address the unique needs of this incredibly thin skin.Check out our next post to see how OS-01 EYE addresses accelarated skin aging.
04
Reverse Biological Aging with the OS-01 peptide
So what can you do to support the delicate skin around your eyes? The answer is OS-01, the first peptide proven to reverse skin’s biological age by reducing the accumulation of senescent cells. [4,5] Stay tuned this month as we reveal key data behind the OS-01 peptide and our latest innovation: OS-01 EYE, a targeted treatment formulated with our highest concentration of the OS-01 peptide to address the unique needs of this incredibly thin skin.Check out our next post to see how OS-01 EYE addresses accelarated skin aging.
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Key Takeaways:
- The skin under the eyes is often the first area on the face to noticeably age
- This ultra-delicate skin is up to 5x thinner than other areas and is more susceptible to collagen loss and environment aggressors.
- Studies have shown that this skin ages faster than other nearby areas of the face.
- Periocular skin shows signs of increased cellular senescence and decreased DNA repair, which may be why we see visible changes so early in our lives.
- OS-01, the breakthrough peptide in our new OS-01 EYE treatment can help: it’s been shown to reduce the accumulation of senescent cells in human skin to maintain healthy and youthful skin.
Key Takeaways:
- The skin under the eyes is often the first area on the face to noticeably age
- This ultra-delicate skin is up to 5x thinner than other areas and is more susceptible to collagen loss and environment aggressors.
- Studies have shown that this skin ages faster than other nearby areas of the face.
- Periocular skin shows signs of increased cellular senescence and decreased DNA repair, which may be why we see visible changes so early in our lives.
- OS-01, the breakthrough peptide in our new OS-01 EYE treatment can help: it’s been shown to reduce the accumulation of senescent cells in human skin to maintain healthy and youthful skin.
References
- https://doi.org/10.1016/j.jaad.2016.02.112
- https://link.springer.com/referencework/10.1007/978-3-662-47398-6
- Vrcek, Ivan et al. “Infraorbital Dark Circles: A Review of the Pathogenesis, Evaluation and Treatment.” Journal of cutaneous and aesthetic surgery vol. 9,2 (2016): 65-72. doi:10.4103/0974-2077.184046
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
References
- https://doi.org/10.1016/j.jaad.2016.02.112
- https://link.springer.com/referencework/10.1007/978-3-662-47398-6
- Vrcek, Ivan et al. “Infraorbital Dark Circles: A Review of the Pathogenesis, Evaluation and Treatment.” Journal of cutaneous and aesthetic surgery vol. 9,2 (2016): 65-72. doi:10.4103/0974-2077.184046
- Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin cells in the OneSkin lab. Explore more at oneskin.co/claims
- https://www.nature.com/articles/s41514-023-00109-1
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
Reviewed by Alessandra Zonari, PhD, Chief Scientific Officer (CSO) and Co-Founder of OneSkin
Alessandra earned her Master’s degree in stem cell biology, and her PhD in skin regeneration and tissue engineering at the Federal University of Minas Gerais in Brazil in collaboration with the 3B’s Research Group in Portugal. Alessandra did a second post-doctoral at the University of Coimbra in Portugal. She is a co-inventor of three patents and has published 20 peer-reviewed papers in scientific journals.
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How To Create A Hydrating Skin Care Routine For Dr...
Senotherapeutics, Senolytics, and Senomorphics -- ...
Cleansing 101: How to Wash Your Face the Right Way...
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Dry Skin 101: How To Identify This Skin Type
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Understanding Oily Skin: Causes & Characteristics
7 Keys to Understanding Menopause and Skin Changes
Is This The Root Cause of Aging?
UV Damage Increases Cellular Senescence. Here's Ho...
Our Research Has Been Published in npj Aging
How To Reduce Hyperpigmentation by Targeting Cellu...
4 Steps to Crafting the Perfect Skin Care Routine ...
A Comprehensive Guide to Understanding and Managin...
An In-Depth Look At The Benefits Of Moringa Oil Fo...
How to Tighten the Skin Under Your Eyes
7 Causes For Crepey Skin Under Eyes
101 Guide To Restoring Dry Skin Around The Eyes
How is OS-01 EYE different from OS-01 FACE?
How to Remove Lingering Dead Skin Cells On the Fac...
Safe Beauty, Validated: Why OneSkin trusts SkinSAF...
Hallmarks of Aging
What is Sensitive Skin?
How OS-01 Works on Mature Skin
Is Fragrance Bad for Your Skin?
Target Cellular Senescence with the Highest Concen...
Can a Plant-Based Diet Really Increase Your Health...
Eye Skin Ages Faster: Here’s How OS-01 Can Help
Gut Health and Skin: How Are They Connected?
The Science Behind Why The Skin Around the Eyes Ag...
How OS-01 EYE Supports the Ultra-Thin Skin Around ...
How Do You Know When to Stop Using Retinol?
How To Heal Skin From Picking Your Face Too Much
Collagen And Elastin: What Role Do They Play In Sk...
Why We Want Skin To Be More, Not Less
More Than Skin Deep: How Physical Touch Predicts L...
What is Skin Inflammation? What Causes it?
How to Reverse (or Prevent) Aging Skin
Yes, You Need Sunscreen During Winter
Can You Use Hyaluronic Acid with Retinol?
Exploring the skin’s purpose in whole-body health
Stressed Skin: 4 Stress Effects on the Skin
What Does Hyaluronic Acid Do For Your Skin?
Good Genes vs. Good Habits: Which Impacts Your Lon...
What Are The Causes Of Dry, Flaky Skin On Your Fac...
What is the Best Skin Care Regimen for Aging Skin?
7 Benefits of Jojoba Oil
What happens to skin as a person ages?
What are the Benefits of Sulforaphane?
8 Benefits of Andiroba Oil For Skin
Invasive vs. Non-Invasive Skincare: The pros and c...
Allantoin For Skin: A Comprehensive Guide
This is the Data to Look For When Choosing Skin Ca...
Why cellular senescence is more than just one of t...
A Simplified Guide To The Different Skin Texture T...
How OS-01 Works With Different Skin Types
How To Smooth Skin Texture On The Face: 4 Expert T...
Skin Microbiome: What It Is, Why it’s Important, A...
What Foods Cause Acne and Which Fight Against It?
The 101 Guide To Understanding Acne-Prone Skin
The Top 4 Prickly Pear Benefits for Skin
What Is Exfoliation & Is It A Necessary Measure Fo...
OneSkin Notable Mention: Dave Asprey's The Human U...
Retinol 101: Debunking Retinol as the Gold Standar...
Menopause & Skin: What you need to know
Take an Inside Look into Our Cutting-Edge R&D Plat...
101 Guide On The Benefits Of Cleansing Your Face
Cleanser Vs. Face Wash: Which Should I Reach For?
Five Common Skin Problems Experienced in Perimenop...
Get to Know OneSkin’s Topical Supplements:
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The Top 3 Benefits of Peptides for Skin
How to Use Peptides In Your Skincare Regimen to Op...
Peptides vs Retinol: Is One Better For Increasing ...
What Is Causing the Uneven Skin Tone On Your Body?
How To Boost Skin Moisture For Your Entire Body Fr...
Three Ways To Extend Your Skinspan Starting With Y...
What Are Free Radicals and How Do They Impact Skin...
The Top 6 Best Antioxidants For Skin Health and Lo...
How OneSkin Developed the OS-01 Peptide
How chronic stress makes you age faster
What is Epidermal Thickness & Why Does it Matter?
Cell Turnover & Why It Slows As We Age
OneSkin Notable Mention: OneSkin Featured In Tony ...
101 Guide To Skin Tightening + 7 Noninvasive Metho...
Tight Feeling Skin: 3 Reasons Why
3 Skin Tightening Ingredients To Help Boost Skin H...
How to Reduce Skin Inflammation & Redness
Niacinamide Vs Retinol: How Do They Compare?
How to Incorporate OneSkin’s OS-01 Topical Supplem...
Why Is Nutrient Absorption Key To Better Skin Heal...
OneSkin Notable Mention: LifeSpan Episode 6 | The ...
The Top 10 Best Foods for Skin Repair
Are There Dangers of Retinol Cream Use?
What is Skin Elasticity & How Can You Improve It?
A Complete Guide to the 4 Stages of Wound Healing
4 Foods To Avoid During Wound Healing & Why
Celebrating Black History Month: A Discussion With...
What is the Function of Skin as a Protective Barri...
Representation of the Black Community in Skin Care...
Our Story: Learn more about the history of OneSkin...
What Is Senescence & Its Relationship To Aging?
Special Announcement: OneSkin to Donate 1% of Sale...
Biological Age: What is Biological Age, Why Does i...
What your skincare routine is missing (Hint. It’s ...
Peptides: The First Piece Of The Skin Longevity Pu...
Health Is The New Wealth
The Correlation Between Sleep and Skin: Why It Mat...
Calorie Restriction And Intermittent Fasting: Eati...
Healthspan: A New Way To Think About Aging